Current Research



Mesenchymal Stem (Stromal) Cells for Treatment of ARDS: a Phase 1 Clinical Trial.

Wilson JG, Liu KD, Zhuo H, Caballero L, McMillan M, Fang X, Cosgrove K, Vojnik R, Calfee C, Lee J, Rogers A, Levitt J, Wiener-Kronish J, Bajwa EK, Leavitt A, McKenna D, Thompson BT, Matthay MA.

Lancet Respir Med. 2014 Dec; 16(14): 70291-70297.


Mesenchymal stem cells: mechanisms of potential therapeutic benefit in ARDS and sepsis.

Walter J, Ware LB, Matthay MA.

Lancet Respir Med. 2014 Dec;2(12): 1016-1026.


Human mesenchymal stem cells reduce the severity of acute lung injury in a sheep model of bacterial pneumonia.

Asmussen S, Ito H, Traber DL, Lee JW, Cox RA, Hawkins HK, McAuley DF, McKenna DH, Traber LD, Zhuo H, Wilson J, Herndon DN, Prough DS, Liu KD, Matthay MA, Enkhbaatar P.

Thorax. 2014 Sep;69(9): 819-25.


Human Mesenchymal Stem (Stromal) Cells Promote the Resolution of Acute Lung Injury in Part through Lipoxin A4.

Fang X, Abbott J, Cheng L, Colby JK, Lee JW, Levy BD, Matthay MA.

J Immunol. 2015 Aug; 195(3): 875-81.


Therapeutic Effects of Human Mesenchymal Stem Cells in Ex Vivo Human Lung Injured with Live Bacteria.  

Lee JW, Krasnodembskya A, McKenna DH, Song Y, Abbott J, Matthay MA.

Am J Resp Crit Care Med. 2013 Apr; 187(7): 751-760.


Concise review: Mesenchymal stem cells for acute lung injury: role of paracrine soluble factors.

Lee JW, Fang X, Krasnodembskaya A, Howard JP, Matthay MA.

Stem Cells. 2011 Jun; 29(6): 913-919.


Antibacterial Effect of Human Mesenchymal Stem Cells is Mediated in Part from Secretion of the Antimicrobial Peptide LL-37.

Krasnodembskaya A, Song Y, Fang X, Gupta N, Serikov V, Lee JW, Matthay MA.

Stem Cells. 2010 Dec; 28(12): 2229-2238.


Therapeutic Potential of Mesenchymal Stem Cells for Severe Acute Lung Injury.

Matthay MA, Thompson T, Read E, Mckenna Jr D, Liu K, Calfee C, Lee JW.

CHEST. 2010 Oct; 138(4): 965-972.


Allogeneic Human Mesenchymal Stem Cells for Treatment of E. Coli Endotoxin-Induced Acute Lung Injury in the Ex Vivo Perfused Human Lung.

Lee JW, Fang X, Gupta N, Serikov V, Matthay MA.

Proc Natl Acad Sci USA. 2009 Sep; 106(38): 16357-16362.


Bone Marrow Stromal Cells Attenuate Sepsis via Prostaglandin E(2)-Dependent Reprogramming of Host Macrophages to Increase Their Interleukin-10 Production.

Németh K, Leelahavanichkul A, Yuen PS, Mayer B, Parmelee A, Doi K, Robey PG, Leelahavanichkul K, Koller BH, Brown JM, Hu X, Jelinek I, Star RA, Mezey E.

Nat Med. 2009 Apr; 15(4): 42-49.


Intrapulmonary Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Survival and Attenuates Endotoxin-Induced Acute Lung Injury in Mice.

Gupta N, Su X, Popov B, Lee JW, Serikov V, Matthay MA.

J Immunol. 2007 Aug; 179(3): 1855-1863.